Fig. 1

Effects of PEA (or OEA) on mechanical allodynia (a and c), on thermal hyperalgesia (b), on duration of immobility in the tail suspension (d), on the index of recognition in the novel object recognition task (e) and on on the number of digging events in the marble burying (f) in sham and SNI mice. Behaviours were determined 30 days after SNI or sham surgery, in presence of vehicle (Pluronic F-68, 5 % v/v) or PEA or OEA (10 mg/kg). Each point represents the mean ± standard error of the mean (S.E.M) of 10–12 mice. ° and * indicate significant differences compared to sham/vehicle and SNI/vehicle, respectively. P < 0.05 was considered statistically significant