Fig. 5
From: Persistent pain alters AMPA receptor subunit levels in the nucleus accumbens
Persistent inflammatory pain causes a reversible increase in GluA1 levels at NAc synapses. a Levels of GluA1 and GluA2 subunits in synaptoneurosome preparations from the NAc did not alter 1 day after CFA injections. Two-way ANOVA with Bonferroni post-test, n = 5 (GluA1), p > 0.05; n = 6 (GluA2), p > 0.05. b Synaptic levels of GluA1 and GluA2 subunits in the NAc did not alter 2 days after CFA injections. Two-way ANOVA with Bonferroni post-test, n = 4–6 (GluA1), p > 0.05; n = 4–6 (GluA2), p > 0.05. c 7 days after CFA administration, levels of GluA1 were selectively increased at NAc synapses, whereas GluA2 levels were not altered. Two-way ANOVA with Bonferroni post-test, n = 8 (GluA1), **p < 0.01; n = 8 (GluA2), p > 0.05. d 14 days after CFA injection, GluA1 levels returned to control levels at NAc synapses, whereas GluA2 levels remained unchanged. Two-way ANOVA with Bonferroni post-test, n = 7–8 (GluA1), p > 0.05; n = 7–8 (GluA2), p > 0.05. Data were normalized to values in the control group. Error bars show mean and SEM