Fig. 1

Fine mapping of the candidate region after the imputation-based association analysis. The circle plot represents the results of the association analysis in a trend model using the GWAS samples. The range for the X-axis represents the genomic position from 55,100,000 to 55,400,000 on chromosome 6 in the HapMap database (http://hapmap.ncbi.nlm.nih.gov/index.html.ja; accessed July 15, 2015). The green object above the plot illustrates the schematic structure of the human HCRTR gene (Gene Accession no. NM_001526.3), based on the NCBI database (http://www.ncbi.nlm.nih.gov/gene/; accessed July 15, 2015). The gene is illustrated between the 5’- and 3’-flanking regions, corresponding to left and right sides, respectively. The green vertical lines and horizontal line that connects them represent the exon and intron, respectively