Rank | CHR | SNP | Position | Genotypeb(FTND ≥ 4) | Genotypeb(FTND < 4) | χ2 | p | Related gene | Region | MAF | TFBS | Splicing | Polyphen |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 6 | rs12333016 | 107205884 | 0/21/42 | 0/4/80 | 20.82 | 5.04E-06 | QRSL1 | intron | 0.08503401 | - | - | - |
2 | 2 | rs11890985 | 116384532 | 2/30/31 | 0/15/70 | 19.21 | 1.17E-05 | DPP10 | 3′ flanking | 0.16554054 | - | - | - |
3 | 13 | rs7984684 | 43517893 | 0/17/43 | 8/45/31 | 19.1 | 1.24E-05 | LOC121838 | 3′ flanking | 0.27083333 | - | - | - |
4 | 5 | rs1009069 | 167806516 | 2/22/39 | 0/9/76 | 16.41 | 5.11E-05 | WWC1 | intron | 0.11824324 | - | - | - |
5 | 5 | rs4958493 | 151090416 | 0/18/45 | 0/4/81 | 16.28 | 5.45E-05 | ATOX1 | 3′ flanking | 0.07432432 | - | - | - |
6 | 6 | rs7754752 | 54272356 | 0/7/56 | 2/33/50 | 16.12 | 5.96E-05 | TINAG | 5′ flanking | 0.14864865 | - | - | - |
7 | 5 | rs4976553 | 167800531 | 4/33/26 | 28/39/18 | 15.56 | 8.01E-05 | WWC1 | intron | 0.45945946 | - | - | - |
8 | 13 | rs7323018 | 43513039 | 3/25/35 | 16/47/22 | 15.46 | 8.42E-05 | LOC121838 | 3′ flanking | 0.37162162 | - | - | - |
9 | 13 | rs4631996 | 98096579 | 0/3/60 | 1/25/59 | 15.06 | 1.04E-04 | LOC643193 | 5′ flanking | 0.10135135 | - | - | - |
10 | 2 | rs10176321 | 235561801 | 7/30/26 | 27/44/14 | 15 | 1.08E-04 | SH3BP4 | intron | 0.47972973 | - | - | - |
11 | 13 | rs1768047 | 98126380 | 0/6/57 | 2/30/53 | 14.99 | 1.08E-04 | SLC15A1 | 3′ flanking | 0.13513514 | - | - | - |
12 | 4 | rs2390944 | 127169897 | 0/4/59 | 1/27/57 | 14.94 | 1.11E-04 | LOC645841 | 5′ flanking | 0.11148649 | - | - | - |
13 | 13 | rs9533755 | 43530210 | 1/20/42 | 11/42/32 | 14.54 | 1.37E-04 | LOC121838 | 3′ flanking | 0.29054054 | - | - | - |
14 | 2 | rs2042831 | 235521853 | 5/36/22 | 26/46/13 | 14.53 | 1.38E-04 | SH3BP4 | 5′ flanking | 0.48648649 | + | - | - |
15 | 2 | rs1542604 | 131309515 | 3/22/38 | 1/9/75 | 14.47 | 1.42E-04 | LOC730032 | 5′ flanking | 0.13175676 | + | - | - |
16 | 1 | rs188158 | 26770729 | 9/33/21 | 4/26/55 | 14.44 | 1.45E-04 | RPS6KA1 | intron | 0.28716216 | - | - | - |
17 | 13 | rs696938 | 92529022 | 8/26/29 | 3/17/65 | 14.37 | 1.50E-04 | GPC6 | 5′ flanking | 0.21959459 | - | - | - |
18 | 10 | rs7924276 | 132704843 | 26/27/10 | 12/44/29 | 14.33 | 1.53E-04 | TCERG1L | 3′ flanking | 0.49662162 | - | - | - |
19 | 12 | rs6488995 | 124375941 | 13/32/18 | 5/32/48 | 14.24 | 1.61E-04 | TMEM132B | 5′ flanking | 0.33783784 | + | - | - |
20 | 13 | rs4772116 | 98100046 | 0/0/63 | 0/17/68 | 14.24 | 1.61E-04 | LOC643193 | 5′ flanking | 0.05743243 | - | - | - |
21 | 1 | rs3895368 | 228949696 | 1/13/49 | 4/42/39 | 14.13 | 1.70E-04 | CAPN9 | 5′ flanking | 0.21959459 | + | - | - |
22 | 5 | rs2973808 | 177699186 | 8/25/30 | 2/19/64 | 13.74 | 2.10E-04 | COL23A1 | intron | 0.21621622 | - | - | - |
23 | 2 | rs4668703 | 11052055 | 22/31/10 | 13/37/35 | 13.63 | 2.23E-04 | KCNF1 | 3′ flanking | 0.46621622 | - | - | - |
24 | 15 | rs12591960 | 87909455 | 3/19/41 | 11/45/28 | 13.62 | 2.24E-04 | C15orf42 | 5′ flanking | 0.31292517 | - | - | - |
25 | 5 | rs9314227 | 97581046 | 6/31/26 | 27/41/17 | 13.46 | 2.44E-04 | LOC642909 | 5′ flanking | 0.46621622 | - | - | - |
26 | 8 | rs3862072 | 65564638 | 7/28/28 | 26/42/17 | 13.41 | 2.50E-04 | BHLHB5 | 5′ flanking | 0.45945946 | - | - | - |
27 | 15 | rs4887435 | 84682665 | 7/26/30 | 0/24/61 | 13.23 | 2.76E-04 | LOC727915 | 5′ flanking | 0.21621622 | - | - | - |
28 | 8 | rs7819541 | 22098096 | 0/4/59 | 4/22/59 | 13.12 | 2.92E-04 | BMP1 | intron | 0.11486486 | - | - | - |
29 | 6 | rs2021678 | 102140234 | 0/5/58 | 3/25/57 | 13.12 | 2.93E-04 | GRIK2 | intron | 0.12162162 | - | - | - |
30 | 18 | rs9303903 | 2433818 | 16/38/9 | 12/35/38 | 12.83 | 3.41E-04 | METTL4 | 3′ flanking | 0.43581081 | - | - | - |
31 | 6 | rs16882180 | 52164345 | 11/35/17 | 6/31/48 | 12.83 | 3.42E-04 | IL17A | 3′ flanking | 0.33783784 | - | - | - |
32 | 7 | rs11771393 | 154410032 | 1/4/58 | 3/27/54 | 12.79 | 3.49E-04 | PAXIP1 | intron | 0.13265306 | - | - | - |
33 | 6 | rs17082273 | 152529619 | 0/2/61 | 0/21/64 | 12.78 | 3.50E-04 | SYNE1 | intron | 0.0777027 | - | + | - |
34 | 16 | rs11862729 | 14053599 | 6/38/19 | 3/31/51 | 12.77 | 3.53E-04 | MKL2 | 5′ flanking | 0.29391892 | - | - | - |
35 | 3 | rs6807108 | 146970672 | 6/30/27 | 3/20/62 | 12.73 | 3.60E-04 | LOC389156 | 3′ flanking | 0.22972973 | - | - | - |
36 | 10 | rs1909669 | 123376244 | 18/34/11 | 9/42/34 | 12.6 | 3.87E-04 | LOC729426 | intron | 0.43918919 | - | - | - |
37 | 13 | rs1927382 | 101940250 | 1/17/45 | 0/6/79 | 12.55 | 3.97E-04 | FGF14 | 5′ flanking | 0.08445946 | - | - | - |
38 | 2 | rs17028222 | 60529867 | 1/10/52 | 3/37/45 | 12.52 | 4.03E-04 | BCL11A | 3′ flanking | 0.18581081 | - | - | - |
39 | 6 | rs2237204 | 16532935 | 14/31/18 | 6/33/46 | 12.51 | 4.04E-04 | ATXN1 | intron | 0.35135135 | - | - | - |
40 | 21 | rs2242936 | 39345341 | 0/8/55 | 1/32/52 | 12.44 | 4.20E-04 | LOC391282 | 5′ flanking | 0.14189189 | - | - | - |
41 | 7 | rs715205 | 122188782 | 0/14/49 | 0/3/82 | 12.44 | 4.21E-04 | CADPS2 | intron | 0.05743243 | - | - | - |
42 | 16 | rs289741 | 55574975 | 7/27/29 | 19/51/15 | 12.4 | 4.29E-04 | CETP | intron | 0.43918919 | - | - | - |
43 | 10 | rs12416632 | 37323355 | 8/24/31 | 21/47/17 | 12.2 | 4.78E-04 | LOC646348 | 5′ flanking | 0.43581081 | + | - | - |
44 | 1 | rs7512726 | 204899584 | 9/34/20 | 3/33/49 | 12.19 | 4.81E-04 | DYRK3 | 3′ flanking | 0.30743243 | - | - | - |
45 | 14 | rs11627505 | 85145744 | 0/15/48 | 9/32/44 | 12.06 | 5.16E-04 | FLRT2 | 5′ flanking | 0.21959459 | - | - | - |
46 | 1 | rs1891243 | 222754068 | 2/28/33 | 1/16/68 | 12.01 | 5.29E-04 | WDR26 | 5′ flanking | 0.16891892 | - | - | - |
47 | 17 | rs2309381 | 5209436 | 24/29/10 | 11/48/26 | 11.99 | 5.35E-04 | RABEP1 | intron | 0.49662162 | - | - | - |
48 | 2 | rs10166654 | 236276002 | 9/25/29 | 26/42/17 | 11.97 | 5.41E-04 | CENTG2 | intron | 0.46283784 | - | - | - |
49 | 7 | rs10230426 | 18699683 | 2/27/34 | 1/15/69 | 11.89 | 5.66E-04 | HDAC9 | intron | 0.16216216 | - | - | - |
50 | 6 | rs2653349 | 55250296 | 0/15/48 | 0/4/81 | 11.8 | 5.92E-04 | HCRTR2 | non-syna | 0.06418919 | - | + | benign |