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Table 4 Results of confirmatory association analysis between the selected SNPs and nicotine dependence

From: Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies

SNP CHR Position Phenotype Exploratory Confirmatory Combined Genotypea(FTND ≥ 4)(CPD > 20) Genotypea(FTND < 4)(CPD ≤ 20) Related gene
     χ2 p χ2 p q χ2 p
rs2653349 6 55250296 FTND 12.3 0.0005921 5.094 0.024 0.048* 14.02 0.0001806 0/41/203 0/17/252 HCRTR2
rs726016 2 234390241 CPD 22.29 0.00000235 0.471 0.4925 0.4925 3.023 0.08209 2/41/94 4/87/293 LOC339766
  1. CHR, chromosome number; Position, chromosomal position (bp); a, distribution of genotype (homozygote of minor allele/heterozygote/homozygote of major allele); *, corrected p < 0.05