Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies

Table 4 Results of confirmatory association analysis between the selected SNPs and nicotine dependence

SNP	CHR	Position	Phenotype	Exploratory		Confirmatory			Combined		Genotype^a(FTND ≥ 4)(CPD > 20)	Genotype^a(FTND < 4)(CPD ≤ 20)	Related gene
				χ²	p	χ²	p	q	χ²	p	Genotype^a(FTND ≥ 4)(CPD > 20)	Genotype^a(FTND < 4)(CPD ≤ 20)	Related gene
rs2653349	6	55250296	FTND	12.3	0.0005921	5.094	0.024	0.048*	14.02	0.0001806	0/41/203	0/17/252	HCRTR2
rs726016	2	234390241	CPD	22.29	0.00000235	0.471	0.4925	0.4925	3.023	0.08209	2/41/94	4/87/293	LOC339766

CHR, chromosome number; Position, chromosomal position (bp); ^a, distribution of genotype (homozygote of minor allele/heterozygote/homozygote of major allele); *, corrected p < 0.05

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