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Fig. 1 | Molecular Brain

Fig. 1

From: A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation

Fig. 1

Activation of quiescent radial glia-like neural stem cells (RGLs) along the septo-temporal axis of the adult hippocampus. a A schematic view of the mouse brain depicting the three-dimensional structure of the hippocampus and the orientation of the sections analyzed in this study. b Representative images of sections used for the analysis from septal (1a) to temporal (4c). The sections were stained with DAPI (grey). Scale bar, 100 μm. c Representative confocal images of immunostaining of MCM2 (red), nestin (green) and DAPI staining (blue) in the septal (left panel) and temporal (right panel) dentate gyrus of the same mouse. Inset, higher magnification views. Scale bars: 100 μm; inset, 25 μm. d Quantitative analysis of MCM2+nestin+ RGLs along the septo-temporal axis. Horizontal axis labels correspond to the numbers in Fig. 1a. Values represent mean ± S.E.M (n = 4)

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Molecular Brain

ISSN: 1756-6606