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Fig. 2 | Molecular Brain

Fig. 2

From: Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients

Fig. 2

Neural differentiation from iPSCs. To study the pathophysiology of ASD using iPSCs-derived neurons, iPSCs need to be differentiated into the disease-relevant neuronal subtype such as cortical neurons. There are general methods currently used for neural induction through embryoid body (EB) formation, cultivation on stromal feeder cells, direct differentiation of iPSCs into neural lineage by lineage specific factors such as Ngn2 or NeuroD1, or direct conversion of somatic cells into neurons by expression of BAM factors and/or microRNAs

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