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Table 1 Behavioral tests for the diagnosis of autistic individuals

From: Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients

  Test methods Description References
Observational report (including questionnaires) Autism Diagnostic Observation Schedule (ADOS) A standardized assessment in terms of objective evaluation of autistic social and communicative behavior symptoms Lord et al. 1989 [39]
Autism Diagnostic Interview-Revised (ADI-R) An interview conducted with the parents of autistic individual to cover autistic individual’s full developmental history Lord et al. 1994 [40]
Clinical Global Impression (CGI) Scale A three-item scale used to assess treatment response in patients with mental disorders Guy 1976 [41]
Childhood Autism Rating Scale (CARS) A score calculated by subjective observation of a child’s behavior across fifteen criteria Schopler et al. 1980 [42]; Mayes et al. 2012 [43]
Autism Behavior Checklist (ABC) A 57-checklist of behavioral characteristics, which has been used for diagnosis of autism Krug et al. 1980 [44]; Volkmar et al. 1988 [45]
Social Responsiveness Scale (SRS) A quantitative measure of autistic traits completed by a caregiver familiar with the autistic individuals within 4–18 year olds Constantino 2002 [46]; Aldridge et al. 2012 [47]
Aptitude test Wechsler Adult Intelligence Scale (WAIS) A form of IQ test designed to measure intelligence in adults and older adolescents, which has separate verbal and non-verbal IQ scores Wechsler 1939 [48]