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Fig. 8 | Molecular Brain

Fig. 8

From: Endothelin-1 induces LIMK2-mediated programmed necrotic neuronal death independent of NOS activity

Fig. 8

Scheme of programmed necrotic neuronal death based on the present data and a previous report [7]. Increased ET-1 release and ETBreceptor expression induced by SE results in the up-regulation of ROCK1 expression, which subsequently increases LIMK2 expression independent of NOS activity. The up-regulated LIMK2 induces necrotic neuronal death by impairment of DRP1-mediated mitochondrial fission. Inhibition of LIMK2 expression and rescue of DRP1 function attenuate this programmed necrotic neuronal death

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