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Fig. 3 | Molecular Brain

Fig. 3

From: Analgesic effects of NB001 on mouse models of arthralgia

Fig. 3

NB001 alleviates arthritic pain behaviors. a Data from the ankle joint arthritic model. A1: The number of spontaneous flinches increased significantly and reached a peak on day 7 following CFA injection and maintained at a higher level as compared with the control. In addition, the score of normal limb use (A2) and forced ambulation (rotarod) (A3) declined significantly after the CFA injection. b Data from the knee joint arthritic model. B1: Mice exhibited a gradually increased spontaneous flinches. The score of normal limb use (B2) and forced ambulation (rotarod) (B3) declined significantly after the CFA injection. NB001 treatment (3 mg/kg, i.p.) significantly attenuated pain-related behaviors in two types of model (a and b). n = 8 in each group. * p < 0.05, ** p < 0.01 compared to the control group; # p < 0.05, ## p < 0.01 compared to the CFA group

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