Fig. 4

NB001 attenuates mechanical allodynia. a Mechanical threshold in the ipsilateral hindpaws decreased in the mice following CFA injection into metatarsal footpad, but had no alteration in the contralateral paws. NB001 administration attenuated the mechanical allodynia in the ipsilateral hindpaws. b The mechanical allodynia occurred gradually following knee intra-articular CFA injection and the threshold decreased obviously from day 17 after initial CFA injection (three days after the third CFA injection), but had no alteration in the contralateral paws. NB001 administration attenuated the mechanical allodynia in the ipsilateral hindpaws. n = 8 mice in each group. ^* p < 0.05, ^** p < 0.01 compared to the control group; ^# p < 0.05, ^## p < 0.01 compared to the CFA group