Fig. 7

Histological staining of ankle and knee joints. The representative sections of ankle joint from control mice (a) and CFA-injection mice (b). CFA injection induced inflammatory cell infiltration, synovium hyperplasia, degeneration of the articular cartilage of the ankle joint. c NB001 treatment (3 mg/kg, i.p.) did not attenuate CFA-induced ankle joint structural destruction. The representative sections of knee joint from control mice (d) and CFA-injection mice (e). Four times knee intra-articular CFA injection induced abnormal structural changes of the knee joint, including bone, synovium, and meniscus. f NB001 treatment (3 mg/kg, i.p.) did not attenuate CFA-induced knee joint structural destruction