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Fig. 1 | Molecular Brain

Fig. 1

From: PARP-1 activity is required for the reconsolidation and extinction of contextual fear memory

Fig. 1

Inhibition of PARP-1 activity in the hippocampus blocks the consolidation of contextual fear memory. a Effects of a micro-infusion of low- or high-dose of 3AB into the dorsal hippocampus at 5 min before training on LTM (VEH, n = 12; 3AB-9 μg, n = 12; 3AB-18 μg, n = 12). b Effects of a micro-infusion of 3AB into the dorsal hippocampus immediately after training on LTM (VEH, n = 13; 3AB, n = 14). c Effects of a micro-infusion of 3AB into the dorsal hippocampus at 5 min before training on STM (VEH, n = 8; 3AB, n = 8). d Effects of a micro-infusion of PJ34 into the dorsal hippocampus at 5 min before training on LTM (VEH, n = 9; PJ34, n = 10). e Effects of a micro-infusion of 3AB into the mPFC at 5 min before training on LTM (VEH, n =15; 3AB, n = 15). *p < 0.05, compared with the VEH group at the test. Error bars indicate SEM

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