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Fig. 2 | Molecular Brain

Fig. 2

From: PARP-1 activity is required for the reconsolidation and extinction of contextual fear memory

Fig. 2

Inhibition of PARP-1 activity in the hippocampus blocks the reconsolidation of contextual fear memory. a, b Effects of a micro-infusion of 3AB into the dorsal hippocampus at 5 min before (a) or immediately after (b) the 3 min re-exposure on PR-LTM (pre-re-exposure infusion: VEH, n = 9; 3AB, n = 10; post-re-exposure infusion: VEH, n = 9; 3AB, n = 10). c Effects of a micro-infusion of 3AB into the dorsal hippocampus immediately after the 3 min re-exposure on PR-STM (VEH, n = 10; 3AB, n = 8). d Effects of a micro-infusion of 3AB into the dorsal hippocampus at 24 h after training without re-exposure on LTM (VEH, n = 9; 3AB, n = 10). e Effects of a micro-infusion of PJ34 into the dorsal hippocampus immediately after the 3 min re-exposure on PR-LTM (VEH, n = 7; PJ34, n = 7). f Effects of a micro-infusion of 3AB into the mPFC immediately after the 3 min re-exposure on PR-LTM (VEH, n = 9; 3AB, n = 10). *p < 0.05, compared with the VEH group at the test. Error bars indicate SEM

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