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Fig. 3 | Molecular Brain

Fig. 3

From: PARP-1 activity is required for the reconsolidation and extinction of contextual fear memory

Fig. 3

Inhibition of PARP-1 activity in the mPFC blocks the long-term extinction of contextual fear memory. a, b Effects of a micro-infusion of 3AB into the mPFC at 5 min before (a) or immediately after (b) the 30 min re-exposure on long-term extinction (pre-re-exposure infusion: VEH, n = 10; 3AB, n = 11; post-re-exposure infusion: VEH, n = 7; 3AB, n = 7). c Effects of a micro-infusion of PJ34 into the mPFC immediately after the 30 min re-exposure on long-term extinction (VEH, n = 8; PJ34, n = 7). d Effects of a micro-infusion of 3AB into the dorsal hippocampus immediately after the 30 min re-exposure on long-term extinction (VEH, n = 9; 3AB, n = 9). *p < 0.05, compared with the VEH group at the test. Error bars indicate SEM

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