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Fig. 4 | Molecular Brain

Fig. 4

From: PARP-1 activity is required for the reconsolidation and extinction of contextual fear memory

Fig. 4

PARP-1 inactivation blocks c-fos induction in the hippocampal CA1 region when memory is consolidated. a, b Effects of a systemic injection of Tiq-A at 30 min before training on LTM (a) and STM (b) (LTM: VEH, n = 8; Tiq-A, n = 8; STM: VEH, n = 10; Tiq-A, n = 10). *p < 0.05, compared with the VEH group at the test. c Experimental design for IHC. d Representative immunohistochemical staining of c-fos-positive cells in the CA1, DG, PL, and IL regions from the indicated mice. Scale bar, 50 μm. e Expression of c-fos in the CA1, DG, PL, and IL regions (n = 7–8 for each group). The expression of c-fos in each group is expressed as the ratio of the no-shock/VEH group to the other groups. *p < 0.05, compared with the other groups. Error bars indicate SEM

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