Fig. 5
From: PARP-1 activity is required for the reconsolidation and extinction of contextual fear memory
PARP-1 inactivation blocks c-fos induction in the hippocampal CA1 region when memory is reconsolidated. a Effects of the systemic injection of Tiq-A at 30 min before the 3 min re-exposure on PR-LTM (VEH, n = 10; Tiq-A, n = 10). *p < 0.05, compared with the VEH group at the test. b Experimental design for IHC. c Representative immunohistochemical staining of c-fos-positive cells in the CA1, DG, PL, and IL regions from the indicated mice. Scale bar, 50 μm. d Expression of c-fos in the CA1, DG, PL, and IL regions (n = 11–17 for each group). The expression of c-fos in each group is expressed as the ratio of the no-shock/VEH group to the other groups. *p < 0.05, compared with the other groups. Error bars indicate SEM