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Fig. 6 | Molecular Brain

Fig. 6

From: VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation

Fig. 6

Restoration of the spine deficit of VPS35+/m hippocampal neurons by expression of GluA2, but not GluA1. a-c Both VPS35+/+ and VPS35+/m hippocampal neurons transfected with GFP-GluA1 or GFP-GluA2 at DIV7 were fixed at DIV 15 and stained with phalloidin. a, b, representative images. Scale bars, 5 μm. c Quantification of spine density in A-B. Data were shown as mean ± SEM; n = 30 neurons from 3 independent experiments; *p < 0.05. d A working model for VPS35-deficiency induced deficits of AMPA receptor trafficking, glutamatergic transmission, and dendritic spine maturation

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Molecular Brain

ISSN: 1756-6606