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Fig. 1 | Molecular Brain

Fig. 1

From: Mesenchymal stem cells suppress neuronal apoptosis and decrease IL-10 release via the TLR2/NFκB pathway in rats with hypoxic-ischemic brain damage

Fig. 1

MSC transplantation improved the learning-memory function and reduced the TLR2/IL-10 expression levels of HIBD rats. a Diagram illustrating the experimental protocols of the treatments and tests used in the rats. b-c The escape latencies and path lengths to reach the visible platform on the first day of the Morris water maze test for the control, HIBD and MSCs rats. d From the 2nd to the 5th day of the Morris water maze test, the escape latencies to locate the visible platform gradually decreased in all three groups. e The duration spent in the former platform quadrant by each of the three groups on the final day of the Morris water maze test. n = 20 in each group. f-g The TLR2 mRNA and protein expression levels in the rat brains on the 3rd, 7th and 14th days following HIBD. n = 5 in each group. h The quantifications of WB signal in g. i The changes in the IL-10 secretion levels in the brains at the three time points after HIBD in all three groups. n = 6 in each group. # P < 0.05 vs. the control group; &P < 0.05 vs. the HIBD group

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