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Table 1 General and clinical characteristics of the study subjects respective of cohort

From: Identification of plasma microRNAs as a biomarker of sporadic Amyotrophic Lateral Sclerosis

Type of cohort Discovery cohort (N = 26) Validation cohort (N = 95)
Patients’ characteristics sALS patients (n = 16) Controls (n = 10) sALS patients (n = 48) Healthy controls (n = 47) Disease controls (n = 30)
Age (mean ± SD) 65.62 ± 9.11 49.30 ± 14.88 66.67 ± 10.52 67.08 ± 10.89 69.00 ± 5.91
Gender (n) Male 9 5 29 29 17
Females 7 5 19 18 13
Disease duration from onset to collection, months (mean ± SD) 17.18 ± 9.29   20.04 ± 18.43   
Initial symptoms (n) Bulbar 3   20   
Upper limb 10   17   
Lower limb 3   11   
ALSFRS-R (mean ± SD) 36.06 ± 10.59   33.15 ± 11.72   
Bulbar paralysis scores of ALSFRS-R (mean ± SD) 9,75 ± 3.51   8.06 ± 4.04   
Barthel Index (mean ± SD) 72.19 ± 31.99   68.02 ± 34.23   
Disease duration from onset to end point, months (mean ± SD) 31.00 ± 13.66   28.58 ± 18.72