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Table 1 General and clinical characteristics of the study subjects respective of cohort

From: Identification of plasma microRNAs as a biomarker of sporadic Amyotrophic Lateral Sclerosis

Type of cohort

Discovery cohort (N = 26)

Validation cohort (N = 95)

Patients’ characteristics

sALS patients (n = 16)

Controls (n = 10)

sALS patients (n = 48)

Healthy controls (n = 47)

Disease controls (n = 30)

Age (mean ± SD)

65.62 ± 9.11

49.30 ± 14.88

66.67 ± 10.52

67.08 ± 10.89

69.00 ± 5.91

Gender (n)

Male

9

5

29

29

17

Females

7

5

19

18

13

Disease duration from onset to collection, months (mean ± SD)

17.18 ± 9.29

 

20.04 ± 18.43

  

Initial symptoms (n)

Bulbar

3

 

20

  

Upper limb

10

 

17

  

Lower limb

3

 

11

  

ALSFRS-R (mean ± SD)

36.06 ± 10.59

 

33.15 ± 11.72

  

Bulbar paralysis scores of ALSFRS-R (mean ± SD)

9,75 ± 3.51

 

8.06 ± 4.04

  

Barthel Index (mean ± SD)

72.19 ± 31.99

 

68.02 ± 34.23

  

Disease duration from onset to end point, months (mean ± SD)

31.00 ± 13.66

 

28.58 ± 18.72