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Fig. 3 | Molecular Brain

Fig. 3

From: Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Fig. 3

The activity of remaining surface NMDARs is down-regulated by the internalization of remote NMDARs. Averages of the normalized P o (bin: 10 s) are shown in a - e. For recordings shown in (a and b), NMDAR-mediated currents were evoked by including high NMDA/glycine (N + G: 1 mM NMDA and 100 μM glycine) in recording pipettes. P o recorded was normalized to the P o during the first bin (control, =100 %). For recordings shown in (c, d and e), NMDAR-mediated currents were evoked by including NMDA (1 mM) and glycine (3 μM) in recording pipettes. P o shown in (c, d and e) was normalized to the mean values of P o (control, = 100 %) before the bath application of glycine at 100 μM. Thick lines indicate X-link applied. *: P < 0.05 (one-way ANOVA test) in comparison with P o of the first bin in (a) or with control before bath application of glycine in (c)

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Molecular Brain

ISSN: 1756-6606