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Fig. 7 | Molecular Brain

Fig. 7

From: Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Fig. 7

Knockdown of PKD1 blocks the NMDAR internalization-induced inhibition of remaining surface NMDARs. a and b show examples of records of P o (bin: 10 s) and summary data (Bar graph) of relative changes in overall P o , t o , B s , C s and S c when compared with that before bath application of 100 μM glycine (a) or 50 μM DHPG (b) (control, dashed line) in neurons infected with PKD1 shRNA. c and d show examples of records of P o and summary data of relative changes in NMDAR channels activity in neurons infected with control shRNA (Ctl. shRNA). e shows examples of averaged mEPSC traces recorded from neurons before and after bath application of DHPG. Bar graphs in f show relative changes in AMPAR and NMDAR components of mEPSCs when compared with control (dashed line) before bath application of DHPG.  *,**P < 0.05, < 0.01 (paired t-test) in comparison with control before glycine or DHPG application

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