Fig. 1From: Bidirectional modulation of hyperalgesia via the specific control of excitatory and inhibitory neuronal activity in the ACCDistinct cell populations and viral expression of rhodopsins in the ACC of CaMKII-cre mice. a Tissue staining of three different markers in the ACC. AAV-DIO-EYFP was injected to ACC of CaMKII-cre mice. CaMKII (EYFP), PV and SOM do not co-localize in the ACC. Dotted polygons indicate one side of ACC. b Optogenetic modulation during multiunit in vivo recording in the ACC of anesthetized mice. 473Â nm light stimulated the basal firing of CaMKII-cre mice injected with AAV-DIO-ChR2-EYFP and 593Â nm light inhibited the basal firing of CaMKII-cre mice injected with AAV-DIO-eNpHR-EYFPBack to article page