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Fig. 5 | Molecular Brain

Fig. 5

From: Bidirectional modulation of hyperalgesia via the specific control of excitatory and inhibitory neuronal activity in the ACC

Fig. 5

Activation of PV-positive interneurons in the ACC alleviates the CFA-induced decrease of the mechanical threshold. a Results of the PV-ChR2 CFA group. There was no effect of blue light before (black) CFA (off: 5.30 ± 0.15 g, on: 5.04 ± 0.07 g; n = 6) however, there was significant effect after (red) CFA injection (off: 3.44 ± 0.11 g, on: 4.55 ± 0.21 g; n = 6) [p = 0.002 in CFA and laser interaction, two-way repeated measures ANOVA]. b Result of current injection experiment with PV-ChR2 mice. A pyramidal neuron in the ACC was current clamped and current was injected without (left) and with blue light (right). Blue dots indicate illumination periods. Firing rates of the pyramidal neurons decreased when light was given. c Result of pulse train experiment with PV-ChR2 mice. A pyramidal neuron in the ACC was current- clamped and current pulses were given for 90 s while light was given for 30 s as indicated by the blue dots. Firing of the pyramidal neurons decreased as a result of illumination. d Result of the SOM-ChR2 CFA group. There was no light effect either before (off: 5.11 ± 0.15 g, on: 4.95 ± 0.11 g; n = 12) or after CFA injection (off: 3.32 ± 0.16 g, on: 3.30 ± 0.13 g; n = 12). e Result of current injection experiment with SOM-ChR2 mice. A pyramidal neuron in the ACC was current-clamped and current was injected without (left) and with blue light (right). Blue dots indicate light on periods. Light had only a small effect on the firing of pyramidal neurons. f Result of pulse train experiment with SOM-ChR2 mice. A pyramidal neuron in the ACC was current- clamped and current pulses were given for 90 s while light was illuminated for 30 s, as the blue dots indicate, but had only a small effect on firing rate

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