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Fig. 5 | Molecular Brain

Fig. 5

From: The novel protein kinase C epsilon isoform modulates acetylcholine release in the rat neuromuscular junction

Fig. 5

nPKCε and adenosine receptors in diaphragm muscles. We produced nerve-delivered stimulation (40 Hz, 2 min of supramaximal stimuli) and analyzed the effect of adenosine (ADO, 10 μM) and the peptide εV1-2 (10 μM) on modulating synaptic depression. We compared the mean size of the first 15 EPPs of each train and the mean size of the last 15 EPPs. The figure shows representative raw data. Horizontal bars: 50 ms. Vertical bars: 10 mV. a Effect of nerve-delivered stimulation (40 Hz, 2 min of supramaximal stimuli) and the normally occurring synaptic depression of the last EPPs in the train. b Effects of ADO in synaptic depression during imposed synaptic activity. c Effect of the peptide εV1-2. d Shows that, in the presence of εV1-2, added ADO cannot protect against depression

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Molecular Brain

ISSN: 1756-6606