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Fig. 3 | Molecular Brain

Fig. 3

From: The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer’s disease

Fig. 3

IGFBP-3 in astrocytes from human brains. Confocal images from a triple-fluorescence immunohistochemical study of β-amyloid stained with FSB (blue) (a and e), astrocytes stained with GFAP (green) (b, f, i and l) and IGFBP3 (red) (c, g, j and m) are shown. D, H, K and N are merged images. Representative images from a control brain (a-d) and an AD brain (e-h) are shown. Higher magnification images from another control (i-k) and from AD patients (l-n) are shown. Little IGFBP-3 was detectable in astrocytes from control brains (c, d, j and k, white arrowheads), whereas increased expression of IGFBP-3 was observed in astrocytes from AD patients (g and h, white arrows), especially in gemistocytic astrocytes (m and n) in the proximity of Aβ plaques. Moreover, IGFBP-3 frequently co-existed with β-amyloid within Aβ plaques (g and h, white circle). These human brain samples were from the temporal cortex

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