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Fig. 3 | Molecular Brain

Fig. 3

From: NMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in mice

Fig. 3

Hbegf deficiency decreases hippocampal NMDA-R expression and plasticity. a, Altered protein expression. Immunoblotting for NMDA receptor subunits (NR1, NR2A and NR2B), PSD-95 and β-tubulin in the hippocampi of control and cKO mice. n = 8 (Control), n = 8 (cKO).b, Micrograph and schematic illustration of a hippocampal slice placed onto the multi-electrode dish. c, Representative traces of fEPSPs before and after the theta burst stimulation. The fEPSPs before and 30 min after the theta burst stimuli are indicated by black and red lines, respectively. d, Time course of normalized fEPSP amplitude after theta burst stimulation. n = 9 (Control), n = 7 (cKO). All results are presented as means ± s.e.m

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