Activation of PKA in the BLA antagonized social defeat-induced anxiety but not social avoidance. a Schematic representation of a protocol for 4-day H-89/8-Br-cAMP administration during the SD stress; b & c The PKA activator 8-Br-cAMP (8-Br) and inhibitor H-89 did not affect the social interaction behaviors; d-g 8-Br-cAMP alleviated SD-induced anxiety in the OFT (d & e) and EPM test (f & g). b, d and f are reconstruction of microinjection sites of the bilateral BLA in different behavioral tests. Histological photomicrograph shows cannula placement in the BLA. *p < 0.05, **p < 0.01 verse NS control.