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Fig. 8 | Molecular Brain

Fig. 8

From: Rasd1, a small G protein with a big role in the hypothalamic response to neuronal activation

Fig. 8

Proposed mechanism of action of Rasd1 in cAMP-dependent gene regulation. Rasd1 mRNA expression is upregulated by glucocorticoid (dexamethasone) and increased plasma osmolality (hypertonic stress). In the cytoplasm RASD1 undergoes posttranslational processing by isoprenylation of its CAAX box motif enabling trafficking to the cell membrane. RASD1 activates Gαi which inhibits the cAMP dependent pathway by inhibiting adenylyl cyclase. This results in the inhibition of the cAMP-PKA-CREB signalling pathway

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