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Fig. 1 | Molecular Brain

Fig. 1

From: Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin

Fig. 1

Growth retardation, defective lamination and foliation in Lrp5/6 dCKO mice. (a, b) The body sizes and body weights of Lrp6 CKO and Lrp5/6 dCKO mice are smaller than those of control and Lrp5 CKO mice. Note that Lrp5/6 dCKO mice die around P17. *p < 0.05, ** p < 0.01 vs WT. (c-j) Overall brain structure is maintained, but the cerebellar lobes (asterisks) in the lateral portion of the cerebellum are invisible in Lrp5/6 dCKO mice at P15. (k-p) Nissl-stained sagittal (k-n) and transverse sections (o, p) show the defective lamination and foliation in the lateral portions (asterisks, p) and anterior vermis (triangles, n) of Lrp5/6 dCKO mice at P15. Cb, cerebellum; Cx, cerebral cortex; IC, inferior colliculus; OB, olfactory bulb; SC, superior colliculus. Scale bars, 600 μm in (n) and applies to (k-m), and 200 μm in (p) and applies to (o)

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