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Fig. 5 | Molecular Brain

Fig. 5

From: Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin

Fig. 5

TH-expressing Purkinje cells maintain their neurochemical characteristics in Lrp5/6 dCKO mice at P17. (a, b) In situ hybridization of GAD67 showing that GABAergic neurons are primarily located in the Purkinje cell layer (Pu) in controls (a), but they are abnormally distributed without a one-cell layer arrangement in Lrp5/6 dCKO mice (b). (c-k) TH-positive cells also express Calbindin (c-e), PV (f-h), and GABA (i-k) in Lrp5/6 dCKO mice. Triangles indicate cells co-expressing TH with Calbindin, PV, and GABA. Scale bars, 200 μm in (b) and applies to (a), and 35 μm in (k) applies to (c-j)

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Molecular Brain

ISSN: 1756-6606