Skip to main content
Fig. 6 | Molecular Brain

Fig. 6

From: Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin

Fig. 6

TH-expressing Purkinje cells do not differentiate into catecholaminergic neurons in Lrp5/6 dCKO mice. (a-c) TH-expressing cells are immunostained with an L-DOPA antibody in the cerebellums of Lrp5/6 dCKO mice at P21. (d-g) Cerebellar cells do not express Dat (d) or AADC (f) at P17. As an internal control, expression of Dat mRNA and AADC mRNA is observed in the substantia nigra (SN) (e) and dorsal raphe nucleus (DR) (g) in Lrp5/6 dCKO mice, respectively. (h, i) No expression of DBH in the cerebellums (Cb) of wide-type (h) and Lrp5/6 dCKO mice (i) at P17. Noted that DBH expression is observed in the locus coeruleus of both genotypes. Scale bars, 30 μm in (a-c), and 100 μm in (d, f, h, i) and 500 μm in (e, g)

Back to article page

Molecular Brain

ISSN: 1756-6606