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Fig. 7 | Molecular Brain

Fig. 7

From: Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin

Fig. 7

Ectopic expression of TH in Purkinje cells is also present in β-catenin CKO mice. (a) Disruption of the laminated architecture in β-catenin CKO mice at P17. (b, c) Many cerebellar cells express GAD67 mRNA in β-catenin CKO mice. (c) Higher magnification of boxed area in (b). (d, e) TH transcripts are abundantly distributed in the cerebellum (Cb) of β-catenin CKO mice at P19. (e) Higher magnification of boxed area in (d). (f-i) TH-immunopositive cells are immunostained with Calbindin (f-h) and PV (i-k) in the cerebellum of β-catenin CKO mice at P17. Scale bars, 670 μm in (a), 445 μm (b, d), 100 μm in (c, e) and 35 μm in (f-k)

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Molecular Brain

ISSN: 1756-6606