Fig. 9

AAV2-Cre virus-mediated gene deletion also induces TH expression in Purkinje cells of β-catenin^flox/flox mice. (a-e) Injection of AAV2-Cre-EGFP virus into P0 cerebellum of β-catenin^flox/flox mice results in Cre-EGFP expression in many Purkinje cells (a), and some of them express TH mRNA (b) and possess TH immnoreactivity (c-e) at P21. (f-i) Mis-expression of Cre-EGFP does not induce TH expression in Purkinje cells of β-catenin^flox/+ mice. Scale bars, 50 μm in (a), 90 μm in (b), 30 μm in (e) and applies to (c, d), 80 μm in (f), 70 μm in (g), 30 μm in (j) and applies to (h, i)