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Fig. 1 | Molecular Brain

Fig. 1

From: Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins

Fig. 1

Complementary expression patterns of the two netrin-G subfamily members in the mouse brain. a Evolutionary tree diagram highlighting the presence of netrin homologs in a wide variety of bilaterally symmetrical organisms. Note that netrin-G family members only exist in vertebrates (With kind permission of Springer Science + Business Media, [87]. b and c Lac-Z staining of NetrinG1-NLS-lacZ-KI and NetrinG2-NLS-lacZ-KI mouse, respectively. The Lac-Z signal localizes only in the nucleus, with largely non-overlapping expression patterns of netrin-G1 and netrin-G2 genes. Images were captured by Nanozoomer (Hamamatsu photonics). d and e Brain slices from netrin-G1-Tau-EGFP and netrin-G2-Tau-mCherry mice show projections and cell bodies of distinct populations of neurons that express netrin-G1 or netrin-G2. Fluorescent images of Tau-EGFP and Tau-mCherry were captured by fluorescent microscopes (FV1000, Olympus) and (Nanozoomer, Hamamatsu photonics), respectively. The fluorescent intensity of Tau-mCherry was amplified by an indirect immunofluorescent technique using anti-mCherry antibodies

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