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Table 1 Summary of behavioral phenotypes of netrin-G1 KO and netrin-G2 KO mice

From: Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins

Classification Test netrin-G1 KO Cohort/Sequence netrin-G2 KO Cohort/Sequence Source
Basic condition and sensory-motor ability Basic condition Appearance light body weight   normal   Nishimura-Akiyoshi et al., 2007
Reflex (righting, posture, eyeblink, ear twitch, whisker orienting) normal 1G/1 normal 2 F/2 data not shown
Sensory ability Optometry normal (enhanced contrast sensitivity) 1B reduced acuity 2I Fig. 2a, b
Visual cliff normal 1G/2 deficits in depth perception 2 F/4 Fig. 2c
ABR normal 1 F/3 deficits 2E/2 Fig. 2d, e
Acoustic startle response normal 1 F/2 deficits 2E/1 Fig. 2f
Foot shock sensitivity normal 1A/4 normal 2A/3 Fig. 2g
Motor ability Low-demand Runway normal 1G/1 normal 2 F/3 DNS
Grip strength normal 1G/1 normal 2 F/3 DNS
High-demand Rotarod normal 1 F/1 deficits (motor coordination or motivation) 2 F/1 Fig. 2h
Hanging wire normal 1G/1 deficits (motor coordination or motivation) 2 F/2 Fig. 2i
Emotion Open field normal 1D/1 low anxiety 2C/1 Fig. 3a, b
Elevated plus maze low anxiety, impulsive behavior 1 J low anxiety K/1 Fig. 3c
Social interaction enhanced interaction to novel mice 1D/3 enhanced interaction to novel and familiar mice 2C/3 Fig. 3d
Fear conditioning attenuated fear response 1A/2 normal 2A/2 Fig. 3e
Cognition Simple-form Nobel object recognition normal 1D/2 normal 2C/2 Fig. 4a, b
Y maze normal 1I/3 hyper activity 2 J/2 Fig. 4c, d
Complex-form Morris water maze (hidden) deficits in goal-directing 1 K deficits in spatial learning and memory 2A/1 Fig. 4e-g
Morris water maze (visible) deficits in goal-directing 1 K normal 2A/1 Fig. 4h
Radial maze slow learning, impulsive behavior 1A/1 working memory deficits 2C/4 Fig. 4i
5CSRTT (learning stage) normal 1I/2 slow procedural learning 2 J/1 Fig. 4j
Attention Home cage abnormal sleep, modest decline in non-selective attention 1I/1 decline in non-selective attention 2G Fig. 5a, b
5CSRTT attention deficit (mainly associated with omission error) 1I/3 attention deficit (mainly associated with erronious poking) 2 J/2 Fig. 5c-d
impulsive tendency 1I/3 impulsive tendency at high-demanding condition 2 J/2 Fig.5f
  1. If same cohorts were subjected for multiple tests, resting periods longer than several days were applied between tests. (1D/1, 2, and 3), (2A/1, 2, and 3), (2C/1, 2, and 3) were carried out in consequtive days