Table 1 Summary of behavioral phenotypes of netrin-G1 KO and netrin-G2 KO mice

Basic condition and sensory-motor ability

Appearance

light body weight

normal

Nishimura-Akiyoshi et al., 2007

Reflex (righting, posture, eyeblink, ear twitch, whisker orienting)

normal

1G/1

normal

2 F/2

data not shown

Optometry

normal (enhanced contrast sensitivity)

1B

reduced acuity

2I

Fig. 2a, b

Visual cliff

normal

1G/2

deficits in depth perception

2 F/4

Fig. 2c

ABR

normal

1 F/3

deficits

2E/2

Fig. 2d, e

Acoustic startle response

normal

1 F/2

deficits

2E/1

Fig. 2f

Foot shock sensitivity

normal

1A/4

normal

2A/3

Fig. 2g

Motor ability

Low-demand

Runway

normal

1G/1

normal

2 F/3

DNS

Grip strength

normal

1G/1

normal

2 F/3

DNS

High-demand

Rotarod

normal

1 F/1

deficits (motor coordination or motivation)

2 F/1

Fig. 2h

Hanging wire

normal

1G/1

deficits (motor coordination or motivation)

2 F/2

Fig. 2i

Open field

normal

1D/1

low anxiety

2C/1

Fig. 3a, b

Elevated plus maze

low anxiety, impulsive behavior

1 J

low anxiety

K/1

Fig. 3c

Social interaction

enhanced interaction to novel mice

1D/3

enhanced interaction to novel and familiar mice

2C/3

Fig. 3d

Fear conditioning

attenuated fear response

1A/2

normal

2A/2

Fig. 3e

Cognition

Nobel object recognition

normal

1D/2

normal

2C/2

Fig. 4a, b

Y maze

normal

1I/3

hyper activity

2 J/2

Fig. 4c, d

Morris water maze (hidden)

deficits in goal-directing

1 K

deficits in spatial learning and memory

2A/1

Fig. 4e-g

Morris water maze (visible)

deficits in goal-directing

1 K

normal

2A/1

Fig. 4h

Radial maze

slow learning, impulsive behavior

1A/1

working memory deficits

2C/4

Fig. 4i

5CSRTT (learning stage)

normal

1I/2

slow procedural learning

2 J/1

Fig. 4j

Home cage

abnormal sleep, modest decline in non-selective attention

1I/1

decline in non-selective attention

2G

Fig. 5a, b

5CSRTT

attention deficit (mainly associated with omission error)

1I/3

attention deficit (mainly associated with erronious poking)

2 J/2

Fig. 5c-d

impulsive tendency

1I/3

impulsive tendency at high-demanding condition

2 J/2

Fig.5f