Fig. 1

Memory formation for conditioned taste aversion (CTA) and latent inhibition of CTA is dependent on gene transcription in the gustatory cortex. a Schematic representation of the behavioral protocol for injection of actinomycin D into the GC, 20 min before drinking of novel taste and i.p. injection with 0.15 M LiCl. b Impaired long memory formation, manifested as reduction in aversion index, in rats injected with actinomycin D before CTA learning. Actinomycin D + CTA (n = 14); Vehicle + CTA (n = 14), *** p < 0.0001. c Schematic representation of the latent inhibition of CTA procedurefor injection of actinomycin D or vehicle, into the GC during the pre-exposure to novel taste at day 5, . At day 8 all the rats undergo CTA and were tested for memory performance three days later. d Impaired latent inhibition of CTA in rats injected with actinomycin D before pre-exposure to novel taste (CTA (n = 8); vehicle + latent inhibition (n = 14); actinomycin D + latent inhibition (n = 14)) ** p < 0.001