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Fig. 1 | Molecular Brain

Fig. 1

From: Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism

Fig. 1

Representative PV+ and VVA+ cells from PND25 mouse cortex. a, b Single channel acquisition of (a) PV+ (magenta) and (b) VVA+ (green) cells. (c, d) Merged images showing PV (magenta) and VVA (green) overlapping in the PND25 cortex of a WT mouse, in (d) additionally with DAPI (light blue) counterstaining. In PV+ cell bodies (magenta), where most of the cell including the nucleus evidenced by DAPI staining (blue) was within the thickness of the section, the PNN (green) surrounding the cell was clearly visible. ad) Low magnification and eh) High magnification images. Arrowheads indicate the PV+VVA+ double-positive neurons that are in focus. In the overlay image, the rim of the cells was lighting up in white, indicative for “co-localization” of PV and VVA. il) High magnification images of PV+ (magenta) and VVA+ (green) cells from PND25 PV-/- mouse cortex. The morphology of PNNs in PV-/- animals does not differ from the one of WT mice. Scale bar: 100 μm (ad), 50 μm (el)

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