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Fig. 7 | Molecular Brain

Fig. 7

From: Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism

Fig. 7

Representative PV immunofluorescence images (a–d) and Western blot analyses (e) from cortex and hippocampus of WT (a, c) and Shank3B-/- (b, d) mice. No apparent differences in the number or signal intensity of PV+ neurons in both brain regions were evident between WT and Shank3B-/- mice. Scale bars in a and b: 100 μm; in c and d: 200 μm. e) Western blot signals from brain homogenates containing cortex and hippocampus showed relatively high signal variability independent of the genotype. For the normalization of the PV signal either the GAPDH Western blot signal (upper part) or the intensity of the Ponceau Red-stained membrane (PR) was used. Results from 3 WT and 3 Shank3B-/-mice are depicted. The positions of the molecular weight markers are indicated. Due to the large difference in signal intensities for GAPDH and PV, the membrane was cut and exposed individually

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Molecular Brain

ISSN: 1756-6606