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Table 3 Mean total number of PV+ and VVA+ cells in the mPFC, SSC and striatum of PV+/+, PV+/-, PV-/-, as well as in PV+/+EGFP reporter mice

From: Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism

 

mPFC PV+

mPFC VVA+

 

Mean

Range

p-value

Mean

Range

p-value

PV+/+

8908

7606–10,417

 

9292

6921–10,987

 

PV+/-

5541

4321–7194

0.0003

9015

7901–10,627

0.3429

PV-/-

--

--

<0.0001

7421

5343–10,589

0.0503

PV+/+ EGFP

8732

6915–9713

0.7861

8664

7202–10,093

0.1079

 

SSC PV+

SSC VVA+

 

Mean

Range

p-value

Mean

Range

p-value

PV+/+

153729

144,549–166,441

 

149709

129,498–169,086

 

PV+/-

95157

82,476–109,745

<0.0001

143609

137,087–154,975

0.4419

PV-/-

--

--

<0.0001

149594

120,020–174,596

0.9925

 

striatum PV+

striatum VVA+

 

Mean

Range

p-value

Mean

Range

p-value

PV+/+

23332

22,384–25,012

 

21724

20,003–24,431

 

PV+/-

11036

8330–13,501

<0.0001

22445

17,158–24,801

0.6613

PV-/-

---

---

<0.0001

20713

17,682–22,348

0.3875

PV+/+ EGFP

18562

17,670–19,681

<0.0001

19881

18,158–21,118

0.0875

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Molecular Brain

ISSN: 1756-6606