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Fig. 3 | Molecular Brain

Fig. 3

From: Endothelial progenitor cells and neural progenitor cells synergistically protect cerebral endothelial cells from Hypoxia/reoxygenation-induced injury via activating the PI3K/Akt pathway

Fig. 3

EPCs and NPCs decreased ROS production via activating the PI3K pathway. A, ROS production, showing that ROS over-production was much decreased in H/R-injured ECs co-cultured with EPCs and NPCs than that co-cultured with EPCs or NPCs alone. LY294002 could diminish the anti-oxidative effect of EPCs and/or NPCs, and the combination of SU1498 and K252a reduce such effect. *p < 0.05, vs. Normoxia; #p < 0.05, vs. Vehicle. Data are expressed as mean ± SEM, n = 6/group/measurement. LY294002: PI3K inhibitor; SU1498: VEGFR2 inhibitor; K252a: TrkB inhibitor

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