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Fig. 4 | Molecular Brain

Fig. 4

From: Endothelial progenitor cells and neural progenitor cells synergistically protect cerebral endothelial cells from Hypoxia/reoxygenation-induced injury via activating the PI3K/Akt pathway

Fig. 4

EPCs and NPCs improved the angiogenic function of H/R-injured ECs via activating the PI3K pathway. a, representative plots of tube formation. Scale bar: 200 μm. b, summarized data of EC tube formation, showing that EPC and NPC co-culture offers synergistically effects on improving EC function compared to EPCs or NPCs alone. And such synergistic effect could be blocked by LY294002, or partially abolished by the combination of SU1498 and K252a. *p < 0.05, vs. Normoxia; #p < 0.05, vs. Vehicle. Data are expressed as mean ± SEM, n = 6/group/measurement. LY294002: PI3K inhibitor; SU1498: VEGFR2 inhibitor; K252a: TrkB inhibitor

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