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Fig. 5 | Molecular Brain

Fig. 5

From: Endothelial progenitor cells and neural progenitor cells synergistically protect cerebral endothelial cells from Hypoxia/reoxygenation-induced injury via activating the PI3K/Akt pathway

Fig. 5

EPCs and NPCs modulated the permeability and VEGF and BDNF secretion of H/R-injured ECs. a fold change of FITC-dextran flux, showing that the combination of EPCs and NPCs has better effects than EPCs or NPCs alone on improving the endothelial barrier function of H/R-injured ECs. b, c the levels of VEGF and BDNF in culture medium of normoxic cultured ECs, EPCs and NPCs, as well as hypoxic ECs co-cultured with EPCs, or NPCs, or both EPCs and NPCs. The summarized data showing that the levels of VEGF and BDNF were much increased in H/R-injured ECs co-cultured with EPCs and NPCs than that co-cultured with NPCs or EPCs alone. *p < 0.05, vs. Normoxia, #p < 0.05, vs. vehicle. Data are expressed as mean ± SEM, n = 6/group/measurement

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