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Fig. 7 | Molecular Brain

Fig. 7

From: Endothelial progenitor cells and neural progenitor cells synergistically protect cerebral endothelial cells from Hypoxia/reoxygenation-induced injury via activating the PI3K/Akt pathway

Fig. 7

Proposed molecular mechanism for the protective effect of EPCs and NPCs on H/R-injured brain ECs. Co-culture with EPCs and NPCs synergistically increased the survival ability, decreased the oxidative stress and improved the angiogenic and barrier functions of H/R-injured EC, via activating the PI3K/Akt signal pathway that mainly depended on the progenitor paracrine (VEGF and BDNF) mediated signals. EPCs: endothelial progenitor cells; NPCs: endothelial progenitor cells; VEGF: vascular endothelial growth factor; BDNF: brain derived neurotrophic factor; VEGFR2: vascular endothelial growth factor receptor 2; TrkB: tyrosin kinase B; PI3K: phosphatidylinositol-3-kinase; H/R: hypoxia/reoxygenation; EC: endothelial cells; ROS: reactive oxygen species

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