Fig. 2

Normal motor coordination, pain sensitivity and sensorimotor function in Sema3F KO mice. a The latency to fall from an accelerating rotarod was measured by three trials per day for two consecutive days in the rotarod test. There was no significant difference in the latency to fall between Sema3F KO mice and WT controls. b The hot plate test was used to evaluate sensitivity to a painful stimulus. Mice were placed on a hot plate and latency to the first hindpaw response was recorded. There was no significant difference in the latency between the genotypes. c, d The startle response/prepulse inhibition tests were performed to examine startle responses to loud stimuli (110 or 120 dB) and inhibition of the startle response by prepulse stimulus (74 or 78 dB). c The startle response and (d) the prepulse inhibition were not significantly different between Sema3F KO mice and WT controls. Data indicate means ± SEM (n = 19 for Sema3F KO mice; n = 20 for WT controls)