Fig. 3

Decreased locomotor activity and increased anxiety-related behavior in Sema3F KO mice. a-d Light/dark transition test. a Distance traveled, (b) number of transitions between the light and dark chambers, (c) latency to enter the light chamber, and (d) stay time in the light chamber (n = 17 for Sema3F KO mice; n = 18 for WT controls). e-h Open field test. e Distance traveled, (f) vertical activity, (g) time spent in center area, and (h) stereotypic behavior counts (n = 19 for Sema3F KO mice; n = 20 for WT controls). i-m Elevated plus maze test. i Number of total entries into arms, (j) distance traveled, (k) percentage of entries into open arms, (l) percentage of time spent in open arms, and (m) time spent in open arms, center area, and closed arms (n = 19 for Sema3F KO mice; n = 20 for WT controls). n-r Social interaction test in a novel environment. n Number of contacts, (o) total duration of contacts, (p) total duration of active contacts, (q) mean duration per contact, and (r) distance traveled (n = 9 for each genotype)