Fig. 1

BDNF facilitates persistent firing and increases excitability of EC layer V pyramidal neurons. a BDNF (50 ng/ml, n = 6) or sub-threshold carbachol (CCh, n = 16) do not induce persistent firing in EC pyramidal neurons following a brief stimulus (100 pA, 1 s) whereas 90 min incubation with BDNF (50 ng/ml) facilitates persistent activity in presence of CCh (n = 11). b Quantification of plateau potential amplitude (*** p = 0.0002, Mann-Whitney test) and frequency (*** p < 0.0001, Mann-Whitney test) of persistent firing. c Input/output curve from pyramidal neurons in slices pre-incubated with vehicle (n = 14) or with BDNF 90 min (n = 21), * p < 0.05, ** p < 0.01, *** p < 0.001, T-test. d Input resistance and resting membrane potential from the pyramidal neurons recorded in C (Rin: * p = 0.028; RMP: * p = 0.0411, Mann-Whitney test)