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Fig. 5 | Molecular Brain

Fig. 5

From: Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex

Fig. 5

BDNF increases glutamate release and mGluR5 is necessary for BDNF-induced facilitation of cholinergic persistent firing. a Representative traces of voltage-clamp recordings of sEPSC from slices treated with vehicle (n = 13), BDNF (50 ng/ml, n = 14), K252a (200 nM, n = 9) and K252a + BDNF (n = 6). b Cumulative probability plot of sEPSC inter-event-intervals (IEI). c Cumulative probability plot of sEPSC amplitudes. d MPEP blocks the facilitation of PF normally induced by BDNF in presence of 5 μM CCh. Quantification of plateau potential amplitudes (e) and persistent firing frequencies (f) (MPEP + BDNF n = 5, MPEP alone n = 9), *** p < 0.001 ANOVA followed by Bonferroni multiple comparison

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