Fig. 6

The proBDNF/p75NTR axis controls glutamate release in the entorhinal cortex. a Representative traces of voltage-clamp recordings of sEPSCs during 5 min (before proBDNF), followed by 10 min of perfusion with proBDNF (2 ng/ml) and then recorded 5 min (proBDNF), followed by 10 min washout with normal ACSF following by 5 min of recording (Wash) (n = 6). b, c Cumulative plots of inter-event intervals and sEPSC amplitudes. d Representative traces of voltage-clamp recording of sEPSCs from slices treated with inactivated (n = 11) or active p75NTR function-blocking antibodies (1/500, n = 10). e Cumulative plots of interevent intervals and sEPSC amplitudes. f Means +/- S.E.M. * p < 0.05 using Kruskal-Wallis ANOVA tests followed by a correction with Dunn test for multiple comparison with vehicle and # p < 0.05 for comparison between conditions with heat-inactivated or active p75NTR antibodies. g Representative traces of paired pulse facilitation recordings from slices treated with vehicle (n = 6), with heat-inactivated p75NTR antibodies (1/500, n = 6) or with active p75NTR antibodies (1/500, n = 6). h Paired pulse ratios, * p < 0.05 One way ANOVA followed by Bonferroni test