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Fig. 8 | Molecular Brain

Fig. 8

From: Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex

Fig. 8

mGluR5 mediates p75NTR-dependent increase in persistent activity. a Typical current-clamp recordings of pyramidal neurons of the entorhinal cortex in brain slices treated with heat-inactivated p75NTR antibodies (1/500, 90 min, n = 6), with function-blocking p75NTR antibodies (1/500, 90 min, n = 5), with MPEP (50 μM, 30 min) followed by an antibody targeting p75NTR (1/500, 90 min) always in presence of MPEP (n = 6), or with MPEP alone (50 μM, 2 h, n = 6). MPEP effectively suppresses the persistent activity normally observed when p75NTR is blocked. b, c Quantification of the plateau potential amplitudes and firing frequencies of persistent activity in different conditions. 0 means no firing (0 Hz) in the condition MPEP + p75NTR antibody. * p < 0.05, One way ANOVA followed by Bonferroni test

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Molecular Brain

ISSN: 1756-6606